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PRODUCT SPOTLIGHT
Organ-on-a-Chip platforms
Organ-on-a-chip (OoC) platforms, are a combination of labs-on-chips and cell biology. Over the years these platforms have attracted a growing interest from scientists in the life-sciences industry. Micronit is involved in several organ-on-a-chip research and customer projects. Our multidisciplinary team has the expertise to offer integrated solutions for specific customer needs. Our devices are already being used in several research labs around the world to create valuable artificial models. Our devices cater to researchers in advanced biomedical engineering, bioMEMS, microfabrication, and microelectronics, serving both research and screening purposes.
Micronit assists in the Organ-on-a-Chip Platform you need
Developing and Manufacturing custom Organ-on-a-Chip platforms
Micronit is an experienced development and manufacturing partner for microfluidic components and consumables. We are open to partners that wish to develop a new product, tailored to their specific wishes and needs. We run multiple projects at different maturity stages from development to manufacturing. Our customers, varying from ambitious start-ups to one of the key global players in the next gen sequencing market, rely on our track record of years of supplying our optical grade, high-quality flow cells and other microfluidic products. We also support leading academics in providing the tools for groundbreaking research.
Standard compatible Organ-on-a-Chip platforms
At Micronit we are always excited when our products can help with new research. This goes to the core of our company's mission: contributing to a healthy and vital life. For this reason, we have developed several OoC platforms that can be ordered directly from our web store. Made from durable glass and membrane materials, they are able to withstand rigorous cleaning and allow for multiple reuses.
The Benefits of Organ-on-a-Chip platforms
Organ-on-a-Chip platforms offer substantial potential in personalized medicine by enabling testing of medicines on actual patient material that provide reliable models for drug development. As a result, the need for animal testing can be reduced.
Micronit has developed an OoC platform which adds flow conditions to static cell culturing in a highly controlled way and supports development of your own tissue model and protocols. By combining the membrane layer with the glass top and bottom layers, a closed cell culturing platform with two separate flow chambers on either side of the cell culturing membrane is created. This allows two different flows of liquids or gases, above and below, driven by an external supply system. With these two flows, a natural growth environment is simulated. The liquids or gases can contain all the substances the cells need, like nutrients. This way, the cultivation process takes place in a very precise and controlled manner and all biologically relevant data can be accurately tracked.
We have chosen membrane materials commonly used in cell culture inserts, ensuring familiarity and reliability for users. The cell culturing membrane is available in several variations, with differences in membrane thickness, pore size and pore density.
Flow quality
Considering the importance of the flow quality in OoC systems, we have put our focus on creating highly accurate flow control options, instead of focusing on the more price focused gravity-based flow concepts. Additionally, we have chosen to use non-permeable rigid materials, in which the oxygen level is fully controlled by the medium. This is opposed to PDMS-based systems, that are supposed to allow oxygen permeation, but in reality show questionable control and stability of this permeation. Furthermore, the materials used in our system (glass and a membrane) do not absorb active ingredients, which is usually an issue in PDMS-based systems due to its molecular structure.
Collaborating with Micronit
What we offer:
- Flexibility: Our platform can be customized to meet specific needs, rather than being limited to a particular organ model.
- Reliability: Based on established cell culture membranes, ensuring proven performance.
- Control: Provides full control over the culturing environment.
- Accessibility: Enables easy access to the flow chamber and bio-content whenever required.
Getting started with your first prototype
in 3 simple steps:
1. Submit your idea
Share your idea or design with us to initiate the prototyping process. We're eager to understand your project's unique requirements.
2. Technical readiness
After receiving your submission and reviewing your design, we'll discuss your specific needs in detail, ensuring alignment with both your objectives and our expertise.
3. Production
Finally, we transition to the technical development and production, transforming your concept into a prototype.
