Would a film degasser give a performance advantage?

A film degasser cannot replace the need for a proper start-up protocol that minimizes the amount of air in the tubing and chip. It is essential to prefill the fluidic lines and flush them before placing the chip into the holder.

Positioning a film degasser just before the chip may help capture and remove bubbles that remain in the system and could otherwise loosen and appear later. In most cases, the effect of dissolved gases in the liquid is minimal as long as the liquid is not oversaturated. One option to further control gas content is to adjust saturation in advance by placing an open reservoir under a vacuum hood before starting the experiment.

Since liquid sheets can be extremely thin—sometimes only a few molecules thick—the presence of gas molecules can significantly impact sheet stability. For this reason, it is strongly recommended to limit gas saturation in the liquid during experiments.