The BRAVO project aims at developing a point-of-care diagnostic test for early detection of rheumatoid arthritis (RA). The test is based on an impedrimetric biosensor integrated in a microfluidic cartridge. The sensor allows multiplex measurement of disease markers to be carried out using a single drop of patients blood as a input, thereby offering a great improvement to the diagnosis and treatment of RA. The integration of the laboratory workflow (i.e., blood filtration and measurement fluidic sequence) in a microfluidic cartridge allows for automation, which results in reduced turn around times and improved test quality. Sensor readout and control, signal processing, data management and presentation software will be integrated in a self-contained reader that will provide a easy-to-use interface to the end user at the point-of-care.